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Canadian Society of Microbiologists Untitled 1

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MEMBERSHIP  ::  Meet the Microbiologist

Meet the Microbiologist

Glycobiology and virulence across gastro-intestinal bacteria and HIV.

My lab is established in the department of Microbiology and Immunology at the University of Western Ontario (London). Our activities revolve around 4 themes:

  1. The mechanisms of synthesis of bacterial surface carbohydrates (glycolipids and glycoproteins) and their role in virulence in gastro-intestinal bacteria Campylobacter jejuni and Helicobacter pylori. We have published many papers describing the biochemical activities of enzymes involved in sugar synthesis, leading to the formation of novel hexoses and heptoses. Our work covers not only the biochemical aspects but also the bacterial genetics and host pathogen interaction aspects.
  2. The study of secreted immuno-modulators from H. pylori, including their mechanism of secretion and their role on interactions with host components.
  3. The investigations of the anti-H. pylori effects of Lactic acid bacteria secretions and their mechanisms of action.
  4. The study of surface protein glycosylation patterns that facilitate transmission of HIV. Though distinct, all themes feed onto one another in terms of concepts and/or techniques, including the HIV studies which capitalize on our expertise in glycobiology.

Related Link

Carole Creuzenet

We investigate the molecular basis for the biosynthesis of surface virulence factors in Campylobacter jejuni and Helicobacter pylori and investigate alternative methods to prevent their pathogenicity. We also study the role of glycosylation in HIV transmission.

Related Website Member Profile

Contact Information
University of Western Ontario
DSB 3031
London, ON N6A 5C1
(519) 661-3204
(519) 661-3499

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CSM-SCM Secretariat
17 Dossetter Way
Ottawa, ON K1G 4S3

Tel: (613) 421-7229

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