Studying Microbiology in Canada
Biochemistry, Microbiology & Immunology
|University of Ottawa
The Department of Biochemistry, Microbiology and Immunology offers graduate programs leading to the degrees of M.Sc. and Ph.D. in microbiology and immunology. It also offers a collaborative specialization in human and molecular genetics for students admitted to the M.Sc. or Ph.D. programs in microbiology and immunology.
- The Department of Biochemistry, Microbiology and Immunology is home to the University of Ottawa Biotechnology Research Institute (UOBRI) which was established in 1985 to promote biotechnology-based research within the University of Ottawa and the local scientific community. The Institute has been providing DNA synthesis, coupled with high pressure liquid chromatography (HPLC) and purification of oligonucleotides to Ottawa area researchers and others since 1987, and in 1995, an automated DNA sequencing and analysis service was added as well.
-The University of Ottawa Flow Cytometry Suite (FCS) is also located in this department.
- Two microbiological centers are based in the BMI Department which provide opportunities for unique research collaborations with industry and others.
- The Centre for Research on Environmental Microbiology (CREM)
- The Centre for Research in Biopharmaceuticals and Biotechnology (CRBB)
- BMI is the home department for the Ottawa Institute of Systems Biology (OISB)
List of Faculty
Addison, Christina - We are interested in the growth of new blood vessels, a process termed angiogenesis, and how this process can be inhibited as a means of preventing tumor growth by starving them of their blood supply.
Altosaar, Illimar - Molecular Bio-Pharming: Production of Human Pharmaceutical Proteins in Transgenic Plants; Reduction of Environmental Carcinogens: Production of Bacterial Entomocidal Proteins (Biocides) in Transgenic Plants.
Angel, Jonathan - Studies on the mechanisms of HIV induced immune dysfunction; Studies on immune restoration with effective anti-HIV therapy; Studies on immune based therapies and vaccines in HIV infection
Aubin, Remy A. - Molecular cloning and functional characterization of genes involved in the pathogenesis of human pancreatic cancer.
Baenziger, John - The structural characterization of membrane proteins with a particular focus on a ligand gated ion channel called the nicotinic acetylcholine receptor (nAChR).
Baetz, Kristin - Using the budding yeast Saccharomyces cerevisiae as our model organism, we aim to integrate directed molecular, genetic and biochemical studies with high-throughput robotics-based chemical and functional genomic techniques to identify and characterize conserved genetic determinants of chromosome stability.
Bell, John - Regulation of pre-mRNA splicing by protein kinases.
Bennett, Steffany - Research in the Bennett laboratory seeks to identify new therapeutic targets that reduce neuronal death and/or activate adult neural stem and progenitor cells to promote functional CNS regeneration.
Birnboim, H. Chaim - Mutatect model for studying genotoxic factors in the tumour microenvironment that may contribute to tumour progression.
Brown, Earl G. - Molecular-genetic analysis of RNA viruses with segmented genomes.
Bulman, Denis E. - Genes involved in Parkinson's Disease; Episodic Neurological Disorders; Ion Channel diseases; Genetic factors in Cardiac Valve Development;
Brachydactyly type A1
Cameron, William - Host-pathogen interaction of Haemophilus ducreyi infection. Epidemiology of sexually transmitted diseases and AIDS in developing countries AIDS clinical epidemiology and treatment trials in Canada Haemophilus ducreyi (chancroid) serology and vaccine development.
Carrier, Danielle - Conformation, dynamics and interactions of membrane lipids in relation with membrane function.
Chrétien, Michel - A group of enzymes called Proprotein Convertases (PCs) play an active role in a number of debilitating conditions whose frequency increases with age (including atherosclerosis, Alzheimer’s disease, AIDS, influenza, obesity and diabetes). This research is expected to produce novel approaches, not only to diagnose and treat these illnesses, but also to prevent them in the future.
Copeland, Karen - The effect of host factors on HIV-1 transcription and replication; The modulation of CD8+ T cell function by HIV-1 infection; Chemokine-mediated signal transduction in T cells and monocytic cells; HIV LTR sequence variation.
De Bold-Kuroski, Mercedes - The role of ovarian hormones on natriuretic peptides (NP) gene expression, production and release in hypertension and in heart failure.
Diaz-Mitoma, Francisco - Pathogenesis of viral infections and the role of cytokines and adhesion molecules in the fight against HIV and hepatitis infections.
Dimock, Kenneth D. - Human enterovirus receptors, co-receptors and entry; enterovirus host range and tropism. Parainfluenza virus fusion and entry; regulation of parainfluenza virus fusion and entry; regulation of paranfluenza virus transcription and replication.
Farber, Jeffrey - Applied food microbiology. Define the conditions leading to the survival, growth and toxin production of pathogenic bacteria in foods; perform molecular typing, search for novel control methods, develop rapid methods.
Figeys, Daniel - To develop proteomic technologies centered on mass spectrometry
Filion, Lionel G. - Cytokine in MS Disease. Cytokine “immune hormones” play an important role in autoimmune disease such as Multiple Sclerosis. The project is to determine the role of the cytokines in modulating the immune response in patients with Multiple Sclerosis.
Franks, Douglas - PKC isoform translocation during cell cycle progression and apoptosis in human breast cancer cells.
Freedman, Mark - Neuroimmunology as applied to the study of MS; Clinical MS research; Therapeutic trials in MS
Garber, Gary - Pathogenesis of Trichiomonas vaginalis
Gray, Douglas - The chain shortening or deubiquitinating enzymes, their substrate specificities, and their potential roles in the development of cancer.
Greenway, Donald – Analysis of compounds of clinical interest by chromatographic and immunological methods; Analysis of porphyrins by HPLC and its application to the differential diagnosis of porphyrias; Automation of immunoassays; Testing for drugs of abuse, analytical and ethical issues; Clinical laboratory automation and robotics; Clinical laboratory utilization.
Haché, Robert - How signaling proteins work in the cell nucleus.
Harper, Mary-Ellen - Mitochondrial Uncoupling Proteins: Mechanisms and their Metabolic Control.
Hefford, Mary - 1) protein chemistry and protein engineering, and 2) protein structure prediction and verification.
Holcik, Martin - (i) Identification of the trans-acting cellular factors that bind to the XIAP IRES and modulate its activity; (ii) analysis of the RNA-protein interactions within the IRES element; (iii) analysis of various apoptotic stimuli and stress situations such as hypoxia, chemotherapeutic drugs and g-irradiation on the expression of XIAP, and other IRES-containing mRNAs; (iv) identification of physiological and pharmacological stimuli which modulate IRES-mediated translation.
Hou, Sheng T. - Identification of novel molecular targets in the complex cascade of post stroke events and on the development of novel experimental strategies for future clinical therapeutics.
Korneluk, Robert G. - Myotonic Muscular Dystrophy (DM): characterization of the DMK gene and its protein product. Role of inhibitors of apoptosis in cancers.
Kozlowski, Maya - To identify the cellular mechanisms and signal transduction pathways modulating the immune responses and development of cancer.
Krishnan, Lakshmi - Development of subunit vaccines against cancers or infection that induce potent long-term memory.
Krworuchko, Marko - HIV-induced defects in immune function; regulation of anti-viral cytotoxic T cell immune responses; cytokine signal transduction.
Kumar, Ashok - HIV Immunopathogenesis
Labow, Rosalind - Identification of the biological activities causing biodegradation of polyurethane medical devices
Laneuville, Odette - The regulation of expression of the enzyme cyclooxygenase
Lee, C. - Heme-Iron Uptake in Neisseria gonorrhoeae.
Lee, Hoyun - The G1/S checkpoint and the S-phase damage-sensing pathway.
Lee, Jonathan - Cancer and the molecular biology of cell division
Li, Sean - Development of genetically modified viral vectors for vaccine and gene delivery; Mechanistic study of SARS viral assembly; Pathogenesis of prion diseases.
Lin, Min - The pathogenic bacterium genes selectively expressed in infected hosts, and roles of these gene products in pathogenesis and immunity
Liston, Peter - Characterization of negative regulators of the Inhibitor of Apoptosis (IAP) protein family, including Smac and XAF1, a candidate tumor suppressor.
Liu, Johné - The molecular mechanism of growth factor signal transduction in cell cycle progression and during early embryonic development.
Lorimer, Ian - Cancer therapeutics targeting a mutant oncogenic EGF receptor; Signalling by mutant EGF receptor; Targeting viral vectors to cells expressing mutant EGF receptor; Phase I trial of an EGF receptor tyrosine kinase inhibitor.
Mackenzie, Alexander - Neuronal apoptosis inhibitory protein (NAIP), assessing its role in modifying the phenotype of the fatal pediatric neuromuscular disorder known as spinal muscular atrophy as well as analysing NAIP gene expression and the protein's mechanism of action.
MacPherson, Paul - Interleukin-7 is essential for the development, maintenance and function of cell mediated immunity.
Mah, Thien-Fah - The lab studies Biofilm-specific antimicrobial resistance using genetic, molecular biological and biochemichal approaches.
Marcel, Yves - Structure-function analysis of human apolipoprotein A-I, cellular cholesterol transport and lipoprotein transcytosis; Role of hepatocyte cell surface molecules in lipoprotein secretion and uptake
Mbikay, Majambu - The biological functions of proprotein convertases (PCs), a seven-member family of calcium-dependent serine proteinases involved in the proteolytic activation of precursor proteins by cleavage after selected pairs of basic residues.
McBride, Heidi - Investigation of the molecular mechanisms governing mitochondrial morphology.
McBurney, Mike - Molecular basis of gene silencing in mammalian cells.
McPherson, Ruth - Structure and function of human apolipoproteins; Adipocyte cholesterol homeostasis; Regulation of adipocyte LRP gene expression.
Milne, Ross - Structure/function relationships of plasma lipoproteins
Nadin-Davis, Susan - Molecular methods towards the development of novel tests for diagnosis of infection by several viruses, as well as exploring improved methods for detection of Salmonella pullorum and discrimination of variants. Rabies molecular epidemiology and virus strain typing.
O'Brien, Edward - The biology of atherosclerosis and the processes involved in arterial narrowing
Parissenti, Amadeo - To study novel and effective approaches to dominantly inhibit/downregulate specific isoforms of protein kinase C or protein kinase A in cells.
Parks, Robin - Development and characterization of adenoviral vectors deleted of all viral protein coding sequences for use in gene therapy.
Pelchat, Martin - characterize the host-components involved in subviral RNA pathogens replication and study their interactions at the molecular level.
Perry, Malcolm B. - Structural and cellular aspects of pathogenesis related to human and animal bacterial infections.
Pickets, David - Human genetic disease arising from defects in epigenetic gene regulation; ATRX, ISWI; Facioscapulohumeral muscular dystrophy (FSHD)
Ramirez, Sandra - Detection of bacterial contamination in blood products ; Development of molecular assays for bacterial detection in blood components ; Bacterial cell division and cell growth ; Cell division mechanisms of Staphylococcus epidermidis.
Sad, Subash - Elucidating the role of cytokines in the differentiation and effector functions of T cells.
Sattar, Syed Abdus - Human Health-Related Environmental Microbiology.
Scoggan, Kylie - diet-gene interactions through the application of genetic and genomic approaches to the field of nutrition
Scott, Fraser - Type 1 Autoimmune Diabetes, Food/Nutritional Modification of Gene and Protein Expression, Inflammation, Cytokines, Mucosal Immunology, Pancreatic Islet Morphogenesis and Stem Cells, Proteomics, Bioactive Food Components, Food Immunology, Environmental Modification of Chronic Disease Risk.
Sikorska-Walker, Marianna - Molecular Mechanisms of Apoptotic Cell Death
Skerjanc, Ilona – How stem cells differentiate into cardiac and skeletal muscle.
Sorisky, Alexander - Obesity, Adipocyte Differentiation, Insulin Action, Apoptosis, Diabetes
Sparks, Daniel - The role of high density lipoprotein charge and structure in the metabolism of cholesterol.
Stintzi, Alain - Functional genomic analysis of Campylobacter jejuni and other enteric pathogens.
Tackaberry, Eilleen - Immunological control of infectious diseases
Tanphaichitr, Nongnuj - Understanding the molecular mechanisms of mammalian fertilization with an emphasis on male germ cells.
Tesson, F. - Determination of Molecular Basis and Genetic Epidemiology of Idiopathic Dilated Cardiomyopathy; Characterisation of Genetic Predictors of Weight Loss in Obese Women
Van Huysse, James - Central nervous control of the cardiovascular system
Vincent, Renaud - The effects of inhaled contaminants on the respiratory, cardiovascular, immune, and central nervous systems using complementary approaches in cell culture models, experimental animals, and human subjects.
Wallace, Valerie - To identify and characterize the cell-cell interactions that regulate proliferation and neurogenesis in the developing mammalian visual system.
Wandeler, Alexander - Rabies Diagnosis, Molecular Epidemiology, Recombinant Vaccines for Wildlife Immunization
Wang, Lisheng - Development of blood and endothelial cells from hESCs, aiming at understanding their developmental biology and generating required tissues for potential clinical applications.
Worton, Ronald - Genetics of human disease (Identification of the dystrophin gene responsible for Duchenne muscular dystrophy; Mechanism of mutation in patients); Gene regulation of the dystrophin gene; Stem Cell and Gene Therapy
Wright, Kathryn - Genetic basis of viral pathogenesis and attenuation, specifically paramyxoviruses.
Yao, Zemin - The pathophysiological mechanisms underlying familial combined hyperlipidemia
Young, Martin - Carbohydrates on cell surfaces and glycoproteins form specific structures that are recognized by proteins such as antibodies and lectins.
Zha, Xiaohui - Cellular Cholesterol Transport and Function.
Financial Support Available
Candidates are encouraged to seek financial assistance by applying directly for scholarships or student loans to provincial, federal or international agencies. Students may be provided full or partial financial support from the research grants of their respective thesis supervisors. Departmental funds for teaching and research assistantships are limited and are generally used for supplementing graduate student stipends.
The Biochemistry Department also offers several financial awards to eligible graduate students.
Admissions and Enquiries
Department of Microbiology and Immunology
Faculty of Medicine
University of Ottawa
451 Smyth Road, Room 4209
Ottawa, Ontario K1H 8M5